一支全副武装的四人特种部队小组奉命赶往出事地点,在自称卫生署官员的欧文医生(Jonathan Mellor 饰)的带领下,他们进入因感染而被封锁的公寓。行动开始不久,成员之一马托斯(Alejandro Casaseca 饰)即遭到攻击和感染。队长帕洛(Juli Fàbregas 饰)深感蹊跷,从欧文口中,他终于知道事件的真相。另一方面,三个少年出于好奇也钻进了公寓,他们经历了种种恐怖的场面,并因此付出代价。与此同时,特种部队和第一集中幸存的女记者安吉拉(Manuela Velasco 饰)相遇,却不知死亡之手已经伸到他们的身边…… 本片是前作《死亡录像》的续集,并荣获2010年戈迪奖最佳剪辑、最佳音效、最佳特效和最佳视觉效果等数项大奖。The medical Dr. Owen leads a three-men SWAT team inside the sealed off building to get blood sample from the girl Medeiros to develop an antidote. They are attacked by the zombie-like creatures and Dr. Owen locks a zombie inside a room using a crucifix. He discloses that the patient zero was possessed by the evil and the Vatican sent him to save mankind. Further, they will only leave the building under his voice command. Meanwhile, three teenagers follow a fireman and a man that breaks into the building through the sewage system to rescue his colleague and daughter respectively and they are trapped inside. They are lured and release the evil creature that was locked by Dr. Owen in a room. Out of the blue, the lead team meets the journalist Ângela Vidal hidden inside the building.